南京医科大学 生物化学与分子生物学系 副教授

科学研究方向：糖尿病发病机制研究

联系方式：电邮：yin@njmu.edu.cn                                        

教育背景及工作经历

2012.09-至今：      南京医科大学        基础医学院     

2010.09-2012.08:     南京医科大学        基础医学院      博士后

2005.09-2010.06： 南京大学       生命科学学院            博士

2001.09-2005.06： 中国药科大学   生物工程专业            学士

奖项及荣誉

2016    教育部科学研究优秀成果奖自然科学奖  二等奖（排名第三）

2016  江苏省科学技术进步奖          二等奖（排名第五）

2016  江苏省高校科研成果奖          二等奖（排名第四）

代表性论文

1、 Mingxia Zhao¹, Lihong Shen¹ , Zijun Ouyang¹, Manru Li, Guoliang Deng, Chenxi Yang, Wei Zheng, Lingdong Kong , Xuefeng Wu , Xudong Wu, Wenjie Guo, Ye Yin#, Qiang Xu#, Yang Sun# Loss of hnRNP A1 in murine muscle exacerbates high fat diet-induced onset of insulin resistance and hepatic steatosis. J Mol Cell Biol . 2020 May 18;12(4):277-290.  

2、 Wen Liu¹, Ye Yin¹, Meijing Wang¹, Ting Fan, Yuyu Zhu, Lihong Shen, Shuang Peng, Jian Gao, Guoliang Deng Xiangbao Meng, Lingdong Kong, Gen-Sheng Feng, Wenjie Guo#, Qiang Xu#, Yang Sun#. Disrupting Phosphatase SHP2 in Macrophages Protects Mice From High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance by Elevating IL-18 Levels J Biol Chem . 2020 Jun 16;jbc.RA119.011840. doi: 10.1074/jbc.RA119.011840.

3、 Yin Y, Yong W, Yu J, Zhang X, Lin H, Zhu Y, Han X#. Pdcd2l Promotes Palmitate-Induced Pancreatic Beta-Cell Apoptosis as a FoxO1 Target Gene. PLoS One. 2016 Nov 18;11(11):e0166692. doi: 10.1371/journal.pone.0166692.  

4、 Yin Y¹, Gao L¹, Lin H, Wu Y, Han X, Zhu Y#, Li J#. Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c. Biochem Biophys Res Commun. 2017 Jan 22;482(4):720-726. doi: 10.1016/j.bbrc.2016.11.101.  

5、 Zhuoxian Meng¹, Ye Yin¹, Jinghuan Lv, Min Sha, Yan Lin, Lu Gao, Yunxia Zhu, Yujie Sun and Xiao Han#  Aberrant activation of liver X receptors impairs pancreatic β-cell function through Sterol Regulatory Element-Binding Protein 1c up-regulation. Diabetologia (2012) 55(6):1733-44.  

6、 Haiyan Lin, Ye Yin, Jiexin Zhang, Hui Xuan, Yue Zheng, Shanshan Zhan, Yunxia Zhu, Xiao Han#  Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal insulin-secreting cells using chromatin immunoprecipitation coupled to DNA selection and ligation. Diabetologia  (2012) 55(10):2703-12

7、 Yan J¹, Zhang H¹, Yin Y, Li J, Tang Y, Purkayastha S, Li L, Cai D#. Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response. Nat Med. 2014 Sep;20(9):1001-8.

8、 Zhang G¹, Li J¹, Purkayastha S¹, Tang Y¹, Zhang H¹, Yin Y, Li B, Liu G, Cai D#. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature. 2013 May 9;497(7448):211-6.