基本情况：

民族： 汉

出生年月：1990年5月

常用邮箱：zxnju1990@gmail.com

教育及工作经历：

2019.07-至今    加州大学戴维斯分校      生物医学       博士后

2019.01-2019.06 罗格斯大学                    生物医学       博士后

2018.02-2018.09 科伦药物研究院            生物部           药理研究员

2012.09-2017.12 南京大学                        药学               博士

2008.09-2012.06  三峡大学                   生物科学            学士

发表论文情况：

1. Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors. Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M, Ding J, Geng M. Cell. 2018 Sep 20;175(1):186-199.e19.

2. Piribedil disrupts MLL1-WDR5 interaction and sensitizes MLL-arrangement acute myeloid leukemia (AML) to doxorubicin-induced apoptosis. Xiong Zhang, Xingling Zheng, Hong Yang, Juan Yan, Xuhong Fu, Rongrui Wei, Xiaowei Xu, Zhuqing Zhang, Aisong Yu, Kaixin Zhou, Xun Huang, Jian Ding, Meiyu Geng. Cancer Lett. 2018 May 29. pii: S0304-3835(18)30367-7. doi: 10.1016/j.canlet.2018.05.034.

3. (+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via activating JAK2-STAT3 signaling pathway. X. Zhang, F. Xu, L. Liu, L. Feng, X. Wu, Y. Shen, Y. S, X. Wu, Q. Xu. Int Immunopharmacol. 2017 Dec;53:1-10.

4. Astilbin prevents free fatty acids induced NLRP3 inflammasome activation and improves insulin resistance in ob/ob mice. Xiong Zhang, Fang Xu,·Yi Sun, Liu Li, Hang Zhou, Yuxiang Ma, Zhe Gao, Wenjie Guo, Xuefeng Wu, Yan Shen, Yang Sun, Xudong Wu, Qiang Xu. Diabetologia.( 2019, in preparation)

5. CUDC-907 suppresses HDAC6 to downregulate c-Myc and enhances therapeutic activity against pancreatic adenocarcinoma. Xuhong Fu, Xiong Zhang, Hong Yang, Xiaowei Xu, Zonglong Hu, Juan Yan, Xingling Zheng, Rongrui Wei, Zhuqing Zhang, Shirui Tang, Meiyu Geng, Xun Huang. Acta Pharmacol Sin. 2018 Sep 17.

6. CTC clusters induced by heparanase enhance breast cancer metastasis. Wei RR, Sun DN, Yang H, Yan J, Zhang X, Zheng XL, Fu XH, Geng MY, Huang X, Ding J. Acta Pharmacol Sin. 2018 Feb 8.

7. Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells. Gao J, Fan M, Xiang G, Wang J, Zhang X, Guo W, Wu X, Sun Y, Gu Y, Ge H, Tan R, Qiu H, Shen Y, Xu Q. Cell Death Dis. 2017 May 4.

8. Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement. Zhou H, Feng L, Xu F, Sun Y, Ma Y, Zhang X, Liu H, Xu G, Wu X, Shen Y, Sun Y, Wu X, Xu Q. Biomed Pharmacother. 2017 May.

9. CPT-11 activates NLRP3 inflammasome through JNK and NF-κB signalings. Li Q, Zhang X, Wang W, Li L, Xu Q, Wu X, Gu Y. Toxicol Appl Pharmacol. 2015 Dec.

10. Neochromine S5 improves contact hypersensitivity through a selective effect on activated T lymphocytes. Gao Z, Ma Y, Zhao D, Zhang X, Zhou H, Liu H, Zhou Y, Wu X, Shen Y, Sun Y, Li J, Wu X, Xu Q. Biochem Pharmacol. 2014 Nov 15.

11. Pentamethoxyflavanone regulates macrophage polarization and ameliorates sepsis in mice. Feng L, Song P, Zhou H, Li A, Ma Y, Zhang X, Liu H, Xu G, Zhou Y, Wu X, Shen Y, Sun Y, Wu X, Xu Q. Biochem Pharmacol. 2014 May 1.