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洪 敏
2021-05-20

洪 敏

南京中医药大学,研究员,博士生导师

地址:南京市栖霞区仙林大道138号,南京中医药大学

电话:0086-25-8581124815805191595

Email: minhong@njucm.edu.cn

 

学习经历:

1998-2002,南京中医药大学,中药药理专业,获博士学位

1995-1998,南京中医药大学,中药药理专业,获硕士学位

1989-1994,中国药科大学,中药药理专业,获学士学位

  

工作经历:

     2012-至今  南京中医药大学,研究员。

2017-2018  美国Drexel大学医学院,访问学者

2007-2008  英国Newcastle大学医学院,博士后,访问学者

2003-2006  南京大学,免疫药理,博士后研究。

2005-2012  南京中医药大学,规范化中药药理实验室,副研究员。

2000-2005南京中医药大学,规范化中药药理实验室,助理研究员。

1998-2000南京中医药大学,规范化中药药理实验室,研究实习员。

1994-1995,哈尔滨松鹤制药厂,质检科

 

代表性论文:

1) Weiyuan Yuan#Yanyan Chen#, Yijing Zhou, Kaifan Bao, Xuerui Yu, Yifan Xu, Yuheng Zhang, Jie Zheng, Guorong Jiang*, Min Hong*. Formononetin attenuates atopic dermatitis by upregulating A20 expression via activation of G protein-coupled estrogen receptor. Journal of Ethnopharmacology 2021 Feb 10;266:113397.

2) Jia Z#, Bao K#, Wei P, Yu X, Zhang Y, Wang X, Wang X, Yao L, Li L, Wu P, Yuan W, Wang S, Zheng J, Hua Y, Hong M*. EGFR activation-induced decreases in claudin1 promote MUC5AC expression and exacerbate asthma in mice. Mucosal Immunology (Mucosal Immunol.) 2020 Mar 4. doi: 10.1038/s41385-020-0272-z. 

3) Wei-Yuan Yuan, Lian-Qu Li, Yan-Yan Chen, Yi-jing Zhou, Kai-Fan Bao, Jie Zheng, Yong-Qing Hua, Guo-Rong Jiang*, Min Hong*. Two flavonoid compounds attenuate allergic asthma by regulat- ing epithelial barrier via G protein-coupled estrogen receptor: Probing a possible target for allergic inflammation. Journal of Leukocyte Biology (J Leukoc Biol.) 2020;1–13.highlighted article in Frontline Science)

4) Kaifan Bao#, Weiyuan Yuan#, Yijing Zhou, Yanyan Chen, Xuerui Yu, Xiaoyu Wang, Zhirong Jia, Xi Yu, Xiaotong Wang, Lu Yao, Siqi Wang, Yifan Xu, Yuheng Zhang, Jie Zheng and Min Hong*. A Chinese Prescription Yu-Ping-Feng-San Administered in Remission Restores Bronchial Epithelial Barrier to Inhibit House Dust Mite-Induced Asthma Recurrence. Frontiers in Pharmacology (Front. Pharmacol.). 2020;10:1698. doi: 10.3389/fphar.2019.01698.

5) Xiaoyu Wang, Yanyan Chen, Weiyuan Yuan, Lu Yao, Siqi Wang, Zhirong Jia, Peng Wu, Lianqu Li, Pan Wei, Xiaotong Wang and Min Hong*. MicroRNA-155-5p is a key regulator of allergic inflammation, modulating the epithelial barrier by targeting PKIα. Cell Death and Disease. 2019 Dec;1012:884.

6) Wang XT, Liu HL, Yu X, Wang C, Gui LL, Wang XY, Hua YQ, Zheng J, Hong M*. Chinese medicine Yu-Ping-Feng-San attenuates allergic inflammation by regulating epithelial derived pro-allergic cytokines. Chinese Journal of Natural Medicines (Chin J Nat Med.) 2019Jul;17(7):525-534. 

7) Yao L, Wang S, Wei P, Bao K, Yuan W, Wang X, Zheng J, Hong M*. Huangqi-Fangfeng protects against allergic airway remodeling through inhibiting epithelial-mesenchymal transition process in mice via regulating epithelial derived TGF-β1. Phytomedicine. 2019 Nov;64:153076. doi: 10.1016/j.phymed.2019.153076. 

8) Zheng Jie#, Wang Xiaoyu#, Tao Yu, Wang Yan, Yu Xi, Liu Hailiang, Ji Lv, Bao Kaifan, Wang Can, Jia Zhirong, Hong Min*. Yu-ping-feng-san ameliorates recurrent allergic inflammation of atopic dermatitis by repairing tight junction defects of epithelial barrier. Phytomedicine, 2019,54(15):214-223.

9) Kaifan Bao, Weiyuan Yuan, Chengbang Ma, Xi Yu, Lei Wang, Min Hong*, Xinping Xi*, Mei Zhou, Tianbao Chen. Modification targeting the “Rana box” motif of a novel nigrocin peptide from Hylarana latouchii enhances and broadens its potency against multiple bacteria. Frontiers in Microbiology (Front. Microbiol.) 2018 Nov;9:2846. 

10) Xiaoyu Wang#, Kaifan Bao#, Xi Yu, Can Wang, Lv Ji, Peng Wu, Min Hong *. Integrative analysis of lncRNAs, miRNAs and mRNA-associated ceRNA network in an atopic dermatitis recurrence model. International journal of molecular sciences (Int J Mol Sci.), 2018;19(10):3263.

11) Li L, Wang Y, Wang X, Tao Y, Bao K, Hua Y, Jiang G, Hong M*. Formononetin attenuated allergic diseases through inhibition of epithelial-derived cytokines by regulating E-cadherin. Clinical Immunology (Clin Immunol). 2018 Oct;195:67-76. 

12) Jia Zhirong, Wang Xiaotong, Wang Xiaoyu, Wei PanLi LianquWu PengHong Min*. Calycosin alleviates allergic contact dermatitis by repairing epithelial tight junctions via downregulating HIF1α. Journal of Cellular and Molecular Medicine (J Cell Mol Med). 2018;22:4507-4521.

13) Wang X, Jiang X, Yu X, Liu H, Tao Y, Jiang G, Hong M*. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions. Journal of Cellular and Molecular Medicine (J Cell Mol Med). 2017; 21(11):2926-36.

14) Yu X, Niu Y, Zheng J, Liu H, Jiang G, Chen J, Hong M*. Radix Saposhnikovia extract suppresses mouse allergic contact dermatitis by regulating dendritic-cell-activated Th1 cells. Phytomedicine. 2015;22(13):1150-8. 




025-89681312
邮箱:yangsun@nju.edu.cn
地址:江苏省南京市栖霞区仙林大道163号南京大学仙林校区      


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