基本情况:

民族：汉  

出生年月：1980年11月

常用邮箱：zhangzc@seu.edu.cn

教育及工作经历：

东南大学，生命科学与技术学院，副研究员

2019.10 – 至今

东南大学，生命科学研究院，副研究员

2012.07 – 2019.10 

美国得州大学西南医学中心，药理系，博士后

2011.07 – 2012.07

美国得州大学西南医学中心    2005.08 – 2011.06

Ph. D，细胞调控专业，导师： Yuh Min Chook

南京大学                                2002.09 – 2005.06

MS，生物化学与分子生物学专业，导师：徐强

南京大学                                1998.09 – 2002.06

BS， 生物化学专业

发表论文情况:

1.  Gu, Q; Wu, J; Tian, Y; Cheng, S; Zhang, Z. C*; Han, J.*; Galphaq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila, J Biol Chem, 2020, 295. (cover paper)

2.  Liu, X; Dou, L. X; Han, J; Zhang, Z. C.*; The Renpenning syndrome-associated protein PQBP1 facilitates the nuclear import of splicing factor TXNL4A through the karyopherin beta2 receptor, J Biol Chem, 2020, 295(13): 4093-4100. (cover paper)

3.  Mu Y.; Tian Y.; Zhang Z.C.*; Han J.*; Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2 , J Biol Chem, 2019, 294(35): 12892-12900.

4.  Guo L.; Kim H.J.; Wang H.; Monaghan J.; Freyermuth F.; Sung J.C.;O'Donovan K.; Fare C.M.; Diaz Z.; Singh N.; Zhang Z.C.; Coughlin M.; Sweeny E.A.; DeSantis M.E.; Jackrel M.E.; Rodell C.B.; Burdick J.A.; King O.D.; Gitler A.D.; Lagier T.C.; Pandey U.B.; Chook Y.M.; Taylor J.P.*; Shorter J.*; Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains , Cell, 2018, 173(3): 677-692.

5.  Zhang X.-Y.; Qi J.; Shen Y.-Q.; Liu X.; Liu A.; Zhou Z.; Han J.; Zhang Z.C.*; Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction, Hum Mol Genetics, 2017, 26(5): 955-968.

6. Tian Y.; Zhang Z.C.; Han J.*; Drosophila Studies on Autism Spectrum Disorders , Neurosci Bull, 2017, 33(6):737-746.

7.  Li Q.; Wang X.; Qi J.; Jin X.; Tong H.; Zhou Z.; Zhang Z.C.; Han J.*; Fbxl4 Serves as a Clock Output Molecule That Regulates Sleep Through Promotion of Rhythmic Degradation of the GABA A Receptor, Curr Biol, 2017, 27(23):3616-3625.

8. Tong H.; Li Q.; Zhang Z.C.; Li Y.; Han J.*; Neurexin regulates nighttime sleep by modulating synaptic transmission , Scientific Rep, 2016, 6(1): 38246-38246.

9.  Wei J.-H.*; Zhang Z.C.; Wynn R. M.; Seemann J.*; GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules, Cell, 2015, 162(2): 287-299.

10. Wan D.#; Zhang Z. C.#; Zhang X.; Li Q.; Han J.*; X-chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs, Hum Mol Genetics, 2015, 24(16):4599-4614.

11. Etchin J.; Sun Q.; Kentsis A.; Farmer A.; Zhang Z. C.; Sanda T.;Mansour M. R.; Barcelo C.; McCauley D.; Kauffman M.; Shacham S.; Christie A.L.; Kung A. L.; Rodig S. J.; Chook Y. M.*; Look A. T.*; Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells, Leukemia, 2013, 27(1): 66-74.

12. Li Y.#; Zhou Z.#; Zhang X.; Tong H.; Li P.; Zhang Z. C.; Jia Z.; Xie W.*; Han J.*; Drosophila neuroligin 4 regulates sleep through modulating GABA transmission, J Neurosic，2013, 33(39): 15545-54.

13. Tian Y.; Li T.; Sun M.; Wan D.; Li Q.; Li P.; Zhang Z. C.; Han J.*; Xie W.*; Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation , Neuron, 2013, 77(2): 311-22.

14. Zhang Z. C.; Chook Y. M.*; Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS), PNAS, 2012, 109(30): 12017-21.

15. Zhang Z. C.; Satterly N.; Fontoura B. M.; Chook Y. M.*; Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1, Mol Biol Cell, 2011, 22(23): 4657-68.

16. Cansizoglu A. E.; Lee B. J.; Zhang Z. C.; Fontoura B. M.; Chook Y. M.*; Structure-based design of a pathway-specific nuclear import inhibitor, Nat Struct & Mol Biol, 2007, 14(5): 452-4.

17. Qian F.; Li Y. P.; Sheng X.; Zhang Z. C.; Song R.; Dong W.; Cao S. X.; Hua Z. C.; Xu Q.*; PRL-3 siRNA inhibits the metastasis of B16-BL6 mouse melanoma cells in vitro and in vivo, Mol Medicine, 2007, 13(3-4): 151-9.

18. Lee B. J.; Cansizoglu A. E.; Suel K. E.; Louis T. H.; Zhang Z.C.; Chook Y. M.*; Rules for nuclear localization sequence recognition by karyopherin beta 2, Cell, 2006, 126(3): 543-58.

19. Qian F.#; Zhang Z. C.#; Wu X. F.; Li Y. P.; Xu Q.*; Interaction between integrin alpha(5) and fibronectin is required for metastasis of B16F10 melanoma cells, Biochem Biophys Res Commun, 2005, 333(4): 1269-75.

20.Zhang Z.C.; Chook Y.M.*; Structural Analysis of Karyopherin-mediated nucleocytoplasmic transport, Landes Bioscienc, 3千字, 2009. (学术专著)

获奖情况：

2017 长三角神经科学青年科学家奖

2017 江苏省自然科学基金优青项目