基本情况:

民族：汉  

出生年月：1980年4月

常用邮箱：wanghp@shanghaitech.edu.cn

教育及工作经历：

2015.07--至今     上海科技大学                                   免疫学  教授

2009.08-2015.07   美国加州大学旧金山分校                         免疫学  博士后

2004.01-2009.07   美国田纳西大学健康医学中心/圣祖德儿童研究医院  免疫学  博士 

1999.09-2003.07   南京大学                                     生物化学  学士

近十年发表论文情况:

1. 通讯作者论文

1、Li W, Qiu S, Chen J, Jiang S, Chen W, Jiang J, Wang F, Si W, Shu Y, Wei P, Fan G, Tian R, Wu H, Xu C, Wang H.*. Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy. Immunity. 2020 Aug 18;53(2):456-470.

2、Liu Q, Zheng J, Sun W, Huo Y, Hao P, Wang H.* Zhuang M.* PUP-IT: Tracking weak protein-protein interactions in and out cells identifies membrane receptor signaling components. Nature Methods.2018.15(9), 715–722.

3、Shang W, Jiang Y, Boettcher M, Ding K, Lai W, Weiss A., Wang H.* A genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation. PNAS.2018 Apr 24;115(17):E4051-E4060

4、Shang W, Wang F, Fan G, Wang H.* Key elements for designing and performing a CRISPR/Cas9-basedgenetic screen. Journal of Genetics and Genomics 2017.44(9):439-449.

5、Chi S ,Weiss A., Wang H.* A CRISPR-Based Toolbox for Studying T Cell Signal Transduction,Biomed Research International,2016 (2314-6141)

2.第一作者论文

1.Tian R#, Wang H#, Pasculescu A, Shi Y, Gish G, Hunter T, Gingras A, Pawson T, Weiss* A.Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T cell co-stimulatory receptor. PNAS. 2015 .112（13）:E1594-E1603.

2. Punwani D#, Wang H#, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM*. Combined Immunodeficiency due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation. J Clin. Immunol. 2015 Feb;35(2):135-46.

3. Wang H#, Flach H#, Onizawa M, Wei L, McManus MT, Weiss A. Negative regulation of Hif1α expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nature Immunology 2014 15;393–401

4. Wang H#, Kadlecek T, Au-Yeung B, Sjölin Goodfellow H, Hsu LY, Freedman T, Weiss A. ZAP-70: an essential kinase in T cell signaling. Cold Spring Harb Perspect Biol. 2010 1;2(5). a002279-a002279.

5. Wang H#, Holst J, Woo S, Guy CS, Bettni M, Wang Y, Aaron S, Naramura M, Mingueneau M, Dragone L,Hayes S, Malissen B, Band H, Vignali DA. Tonic Ubiquitylation controls T cell receptor:CD3 complex expression during T cell development. EMBO J. 2010 7;29(7):1285-98.

获奖情况：

1、2018年  中科院分子细胞科学卓越创新中心青年骨干

2、2018年  罗氏制药（国际）研发资助

3、2015年  入选“国家高层次人才计划”

4、2014年  美国国立卫生研究院T32奖学金