2017年度Molpharm Lab发表文章
1. W Guo, W Liu, Z Chen, Y Gu, S Peng, L Shen, Y Shen, X Wang, GS Feng, Y Sun*, Q Xu*. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun 2017, DOI: 10.1038/s41467-017-02351-0

HightlightThe NLRP3 inflammasome is central to a variety of inflammatory diseases, but how it is regulated to prevent excessive inflammation is not clear. Here we show that NLRP3 activation causes SHP2 translocation to the mitochondria to interact with and dephosphorylate ANT1, thus stabilizing the mitochondria and preventing release of proinflammatory mitochondrial DNA and ROS.





2. W Liu, W Guo, L Shen, Z Chen, Q Luo, X Luo, GS Feng, Y Shu, Y Gu*, Q Xu*, Y Sun*. T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. Oncotarget 2017; 8:7586-7597.

Hightlight
Nonresolving inflammation is involved in the initiation and progression process of tumorigenesis. SHP2 is known to inhibit acute inflammation but its role in chronic inflammation-associated cancer remains unclear. Here we show that T lymphocyte SHP2-defciency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.




3. Y Tan, Wu X, Sun J, Guo W, Gong F, Shao F, Tan T, Cao Y, Zheng B, Y Gu, Y Sun*, Q Xu*. A fumigaclavine C isostere alleviates Th1-mediated experimental colitis via competing with IFN-gamma for binding to IFN-gamma receptor 1. Biochem Pharmacol 2017 123, 63-72.



4. ZJ Ouyang, XQ Wang, QQ Meng, LL Feng, Y Sun, XF Wu*, Q Xu*. Suppression of adenosine monophosphate-activated protein kinase selectively triggers apoptosis in activated T cells and ameliorates immune diseases. Biochem Biophys Res Commun 2017;487:223-229.
5. ZJ Ouyang, WS Li, QQ Meng, Q Zhang, XQ Wang, A Elgehama, XD Wu, Y Shen, Y Sun, XF Wu*, Q Xu*. A natural compound jaceosidin ameliorates endoplasmic reticulum stress and insulin resistance via upregulation of SERCA2b. Biomed Pharmacother 2017;89:1286-1296.
6. X Zhang, F Xu, L Liu, L Feng, X Wu, Y Shen, Y Sun, X Wu*, Q Xu*. (+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway. Int Immunopharmacol 2017;53:1-10.
7. H Zhou, L Feng, F Xu, Y Sun, Y Ma, X Zhang, H Liu, G Xu, X Wu, Y Shen, Y Sun, X Wu*, Q Xu*. Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement. Biomed Pharmacother 2017;89:864-874.
8. Y Hu, X Li, W Xue, J Pang, Y Meng, Y Shen*, Q Xu*. TP53INP2-related basal autophagy is involved in the growth and malignant progression in human liposarcoma cells. Biomed Pharmacother 2017;88:562-568.
9. J Gao, M Fan, G Xiang, J Wang, X Zhang, W Guo, X Wu, Y Sun, Y Gu, H Ge, R Tan, H Qiu*, Y Shen*, Q Xu*. Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells. Cell Death Dis 2017;8(5):e2765.
10. J Gao, M Fan, S Peng, M Zhang, G Xiang, X Li, W Guo, Y Sun, X Wu, X Wu, G Liang, Y Shen*, Q Xu*. Small molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer. Cell Death Dis 2017;8(9):e3049.
11. X Li, TT Lu, WW Xue, YX Wang, Q Luo, HM Ge, RX Tan, Y Shen*, Q Xu*. Small molecule-mediated upregulation of CCR7 ameliorates murine experimental autoimmune encephalomyelitis by accelerating T-cell homing. Int Immunopharmacol 2017; 53:33-41.  

 

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