1. W Guo, Y Sun*, W Liu, X Wu, L Guo, P Cai, XF Wu, Y Shen, Y Shu, Y Gu*, Q Xu*. Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer. Autophagy, 2014;10:972-985. Download
 
Highlight: Nonresolving inflammation in the intestine predisposes individuals to the development of colitis-associated cancer (CAC). Inflammasomes are thought to mediate intestinal homeostasis, and their dysregulation contributes to inflammatory bowel diseases and CAC. However, few agents have been reported to reduce CAC by targeting inflammasomes. Here we show that the small molecule andrographolide (Andro) protects mice against azoxymethane/dextran sulfate sodium-induced colon carcinogenesis through mitophagy-mediated NLRP3 inflammasome inhibition. Our data may help guide decisions regarding the use of Andro in patients with inflammatory bowel diseases, which ultimately reduces the risk of CAC.




2. Q Luo, Y Sun*, F Gong, W Liu, Y Shen, Y Ke, Z Hua, Y Gu, Y Shu, Q Xu*. Blocking initial infiltration of pioneer CD8+ T-cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice. Brit J Pharmacol 2014; 171: 1706-1721. Download

Highlight: In contrast to T cell priming in the periphery, therapeutic strategies targeting the initiation step of T cell trafficking into the central nervous system (CNS) have not been extensively investigated. In this study, NSC-87877 almost completely abolished the development of EAE by blocking the initial infiltration of pioneer CD8+ T cells into the uninflamed CNS. These results reveal a critical role for SHP-2 in regulating EAE pathogenesis and support NSC-87877 as a potential lead compound for the treatment of relapsing-remitting multiple sclerosis.




3. L Wang, W Li, Y Yang, Y Hu, Y Gu, Y Shu, Y Sun, X Wu, Y Shen*, Q Xu*. High expression of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2b blocks cell differentiation in human liposarcoma cells. Life Sciences 2014; 99: 37-43.


4. W Liu, W Guo, L Guo, Y Gu, P Cai, N Xie, X Yang, Y Shu, Y Sun, Q Xu. Andrographolide sulfonate ameliorates experimental colitis in mice by inhibiting Th1/Th17 response. Int Immunopharmcaol 2014, 20: 337-345.


5. P Cai, W Guo, H Yuan, Q Li, W Wang, Y Sun*, X Li, Y Gu. Expression and Clinical Significance of Tyrosine Phosphatase SHP-2 in Colon Cancer. Biomed Pharmacother 2014;68: 285-290.




6. W Li, Z Ouyang, Q Zhang, L Wang, Y Shen, Y Gu, Y Shu, B Yu, X Wu, Y Sun*, Q Xu*. SBF-1, a potential sarco/endoplasmic reticulum Ca2+-ATPase 2 inhibitor, induces endoplasmic reticulum stress-mediated cell death in human cervical cancer cells. Cell Death & Disease 2014; 5, e1581.

Highlight: Cervical cancer is one of the most common carcinomas in genital system. In the present study, we report that SBF-1, a synthetic steroidal glycoside, has a strong anti-growth activity against human cervical cancer cells in vitro and in vivo. Our results suggest that SBF-1 disrupts Ca2+ homeostasis and causes ER stress-associated cell death through directly binding to SERCA2 and inhibiting SERCA activity. These findings also indicate that SERCA2 is a potential therapeutic target for human cervical cancer.








7. X Wang, A Zhang, J Gao, W Chen, S Wang, X Wu, Y Shen, Y Ke, Z Hua, R Tan*, Y Sun*, Q Xu*. Trichomide A, a natural cyclodepsipeptide, exerts immunosuppressive activity against activated T lymphocytes by up-regulating SHP2 activation to overcome contact dermatitis. J Invest Dermatol 2014; 134(11):2737-46.


Highlight: Increasing numbers of people are suffering from allergic contact dermatitis. However, the immunosuppressive drug candidate with negligible toxicity is still deficient. In the present study, we have demonstrated that trichomide A inhibits activated T cells by triggering SHP2 activation, which contributes to the improvement of contact hypersensitivity.Taken together,trichomide A showed an immunosuppressive activity against T cell–mediated immune responses both in vitro and in vivo, which has potential for the treatment of immune-related skin diseases.
 



8. X Wu, F Shao, Y Yang, L Gu, W Zheng, X Wu, Y Gu, Y Shu, Y Sun*, Q Xu*. Epigallocatechin-3-gallate sensitizes IFN-γ-stimulated CD4+ T cells to apoptosis via alternative activation of STAT1. Int Immunopharmacol 2014; 23(2):434-41.

9. W Guo, W Liu, B Jin, J Geng, J Li, H Ding, X Wu, Q Xu, Y Sun*, J Gao*. Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation. Int Immunopharmacol 2014; 24(2):232-238.

10. XF Wu, ZJ Ouyang, LL Feng, G Chen, WJ Guo, Y Shen, XD Wu, Y Sun*, Q Xu*. Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone. Toxicol Appl Pharma 2014;281: 146-156.

11. Z Gao, Y Ma, D Zhao, X Zhang, H Zhou, H Liu, Y Zhou, X Wu, Y Shen, Y Sun*, J Li, X Wu*, Q Xu*. Neochromine S5 improves contact hypersensitivity through a selective effect on activated T lymphocytes. Biochem Pharmacol 2014; 92(2):358-68.

12. X Wu, J Fan, Z Ouyang, R Ning, W Guo, Y Shen, X Wu, Y Sun*, Q Xu*. Tupistra chinensis extract attenuates murine fulminant hepatitis with multiple targets against activated T lymphocytes. J Pharm Pharmacol 2014;66(3):453-65.

13. Q Luo, Y Sun*, B Jin, W Zheng, F Shao, Y Shu, X Li, Y Gu*, Q Xu*. Iguratimod synergizes with methotrexate to exert anti-inflammatory and bone-protective effect and block the progression of collagen-induced arthritis in mice. Biochem Pharmacol Open Access 2014, 3:135

 

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