1.Xiaopeng Wu,* Hu Zeng, Xianming Zhang,* Ying Zhao,* HaiboSha, XiaomeiGe, Minyue Zhang, Xiang Gao and Qiang Xu. Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells. The American Journal of Pathology. 2004; 164(6): 2039-2054.

Highlight: Recent reports suggested that phosphatase of regenerating liver (PRL)-3 might be involved in colorectal carcinoma metastasis with an unknown mechanism. Here we demonstrated that PRL-3 expression was up-regulated in human liver carcinoma compared with normal liver. PRL-3 was also highly expressed in metastatic melanoma B16-BL6 cells but not in its lowly metastatic parental cell line, B16 cells. B16 cells transfected with PRL-3 cDNA displayed morphological transformation from epithelial-like shape to fibroblast-like shape. PRL-3-overexpressed cells showed much higher migratory ability, which could be reversed by specific anti-sense oligodeoxynucleotide and the phosphatase inhibitors sodium orthovanadate or potassium bisperoxo oxovanadate V. Meanwhile, the expression of the catalytically inactive PRL-3 mutations (D72A or C104S) significantly reduced the cell migratory capability. In addition, PRL-3 transfectants demonstrated altered extracellular matrix adhesive property and up-regulated integrin-mediated cell spreading efficiency. Furthermore, we confirmed that PRL-3 could facilitate lung and liver metastasis of B16 cells in an experimental metastasis model in mice, consistent with accelerated proliferation and growth rate both in vitro and in vivo. Together, these observations provide convincing evidence that PRL-3 truly plays a causal role in tumor metastasis.

2. Chao Tu, Ying Shao, NingGan, Qiang Xu and Zijian Guo. Oxidative DNA Strand Scission Induced by a Trinuclear Copper(II) Complex.Inorg. Chem. 2004; 43: 4761-4766.
3.Xianming Zhang, Shaopeng Huang, Qiang Xu. Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway. Cancer Chemother. Pharmacol. 2004; 53(1): 82-88.
4.Jianming Guo, Qiang Xu and Ting Chen. Quantitative determination of astilbin in rabbit plasma by liquid chromatography. J. Chromatography B 2004; 805: 357-360.
5.Chao Tu, Xuefeng Wu, Qin Liu, Xiaoyong Wang, Qiang Xu, Zijian Guo. Crystal structure, DNA-binding ability and cytotoxic activity of platinum(II) 2, 2’-dipyridylamine complexes.Inorg. Chim. Acta 2004; 357:95-102.
6.J. Chen, X. M. Zhang and Q. Xu. Involvement of lymphocytes with a Th1 cytokine profile in bone cell damage associated with MMP-9 production in collagen-induced arthritis. Inflamm. Res. 2004; 53:670-679.
7.Jun Wang, Ying Zhao and Qiang Xu. Astilbin prevents concanavalin A-induced liver injury by reducing TNF-α production and T lymphocyte adhesion. J. Pharm. Pharmacol. 2004; 56: 495-502.
8.Ying Zhao, Junyan Liu, Jun Wang, Lei Wang, Hao Yin, Renxiang Tan and Qiang Xu. Fumigaclavine C improves concanavalin A-induced liver injury in mice mainly via inhibiting TNF-α production and lymphocyte adhesion to extracellular matrices. J. Pharm. Pharmacol. 2004; 56: 775-782.
9.Jing Gao, Xinhui Tang, Huan Dou, Yimei Fan, Xiaoning Zhao and Qiang Xu. Hepatoprotective activity of Terminaliacatappa L. leaves and its two triterpenoids. J. Pharm. Pharmacol. 2004; 56: 1449-1455.
10. Xin-hui Tang, Ling Gao, Jing Gao, Yi-mei Fan, Li-zhiXu, Xiao-ning Zhao and Qiang Xu. Mechanisms of Hepatoprotection of TerminaliaCatappa L. Extract on D-Galactosamine-induced Liver Damage. The American Journal of Chinese Medicine. 2004; 32 (4): 509-519.


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