1. Feng Qian,Yupei Li, Xia Sheng, Zichao Zhang, Ran Song, Wei Dong, Shaoxian Cao, Zichun Hua,Qiang Xu. PRL-3-siRNA Inhibits the Metastasis of B16-BL6 Mouse Melanoma Cells in vitroand in vivo. Mol. Med.2007; 13(3-4):151-9. Erratum in: Mol Med. 2007 May-Jun;13(5-6):325.

2. Jianming Guo,Qiang Xu,Ting Chen. Identification of a new metabolite of astilbin, 3'-O-methylastilbin, and its immunosuppressive activity against contact dermatitis. Clin.Chem. 2007;53: 465-471.


Highlight: Astilbin is a flavonoid isolated from the rhizome of Smilax glabra. In a previous study, we revealed its unique immunosuppressive activity, a selective inhibition against activated T lymphocytes. We characterized this metabolite by MS and NMR techniques as 3'-O-methylated astilbin. We detected the metabolite in both blood and urine samples after oral administration of astilbin, and the metabolite inhibited picryl chloride-induced ear swelling in mice and suppressed the expression of tumor necrosis factor-alpha and interferon-gamma, similarly to astilbin. This is the first identification of 3'-O-methylastilbin as a new flavonoid, as well as an active metabolite of astilbin in vivo, and is helpful for studying the kinetics of astilbin and its clinical applications.

3. Jingwen Chen, Xiaoyong Wang, Ying Shao, Jianhui Zhu, Yangguang Zhu, Yizhi Li, Qiang Xu, Zijian Guo. A trinuclear copper(II) complex of 2, 4, 6-tris(di-2-pyridylamine)-1,3,5-triazine showsprominent DNA cleavage activity. Inorg. Chem.2007; 46: 3306-3312.
4. Yan Shen,Jia Chen, Xianming Zhang, QiangXu.Human TNF-alpha gene vaccination ameliorates collagen-induced arthritis in mice. Int. Immunopharmacol. 2007; 7: 1140-1149.
5. Sheng X, Lu XM, Zhang JJ, Chen YT, Lu GY, Shao Y, Liu F, Xu Q. Synthesis and DNA cleavage activity of artificial receptor 1,4,7-triazacyclononane containing guanidinoethyl and hydroxyethyl side arms. J. Org. Chem. 2007; 72(5): 1799-802.
6.Liang Chen, Ye Yin, Hongwei Yi, QiangXu, Ting Chen. Simultaneous quantification of five major bioactive flavonoids in RhizomaSmilacisGlabrae by high-performance liquid chromatography. J. Pharmaceutical Biomed. Anal.. 2007; 43: 1715-20.
7.Xiao-Min Lu, Hong-Wei Yi, Jian-Liang Xu,Yang Sun, Jian-Xin Li, Shao-Xian Cao, QiangXu. A novel synthetic oleanolic acid derivative with amino acid conjugate suppresses tumor growth through inducing cell cycle arrest. J. Pharm. Pharmacol. 2007;59(8): 1087-93. 
8. Guo-Biao Liu, Yi-Zhi Li, Yong-Miao Shen, QiangXu, Jian-Xin Li. N-(2-Acetyl-3,5-dimethoxyphenyl)acetamide.ActaCryst.2007; E63: o2420-o2421.
9.Zhang J, Sun Y, Liu JH, Yu BY, Xu Q. Microbialtransformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure-activity relationship (SAR). Bioorg. Med. Chem. Lett. 2007; 17(22): 6062-6065.
10. Xin Sheng, Xiao-Min Lu, Yue-Ting Chen, Guo-Yuan Lu, Jing-Jing Zhang, Ying Shao, Fang Liu, Qiang Xu. Synthesis, DNA binding, cleavage, and cytotoxic activity of new 1, 7-dioxa-4,10-diazacyclododecane artificial receptors containing bisguanidinoethyl or diaminoethyl double side arms. Chem-Eur.J.2007; 13: 9703-9712.
11. Xiao-Yu Guo,Nai-Li Wang, Li Bo, Yi-Hua Li, Qiang Xu, Xin-Sheng Yao. Chemical constituents from Pithecellobiumclypearia and their effects on the T lymphocytes proliferation. Journal of Chinese Pharmaceutical Sciences 2007; 16: 208-213.


 

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