1.WJ Guo, YM Zhang, L Zhang, B Huang, FF Tao, W Chen, ZJ Guo, Q Xu*, Y Sun*. Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin. Autophagy 2013; 9: 996-1008. (*correspondence-authorship) Download

Highlight: Failure to engage apoptosis appears to be a leading mechanism of resistance to traditional platinum drugs in patients with ovarian cancer. Therefore, an alternative strategy to induce cell death is in need for the chemotherapy of this type of cancer. This paper reports that autophagic cell death, distinct from cisplatin-induced apoptosis, is triggered by a novel monofunctional platinum (II) complex named Mono-Pt in human ovarian carcinoma cells. Our results suggest that Mono-Pt can exert anticancer effect via autophagic cell death in apoptosis-resistant ovarian cancer. These findings lead to increased options for anticancer platinum drugs to induce cell death in cancer.



2. W Liu, W Guo, J Wu, Q Luo, F Tao, Y Gu, Y Shen, J Li, R Tan, Q Xu*, Y Sun*. A novel benzo[d] imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome. Biochem Pharmacol, 2013, 85: 1504-1512. (*correspondence-authorship)
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Highlight: NLRP3 inflammasome has been reported to be associated with various kinds of immunological diseases including colitis. However, there are few drug candidates targeting inflammasomes for the treatment of colitis. This paper aimed at examining the effect of 1-ethyl-5-methyl-2-phenyl-1H-benzo[d]imidazole, a synthetic small molecular compound also named Fc11a-2, for the treatment of dextran sulfate sodium (DSS)-induced experimental colitis in mice via targeting NLRP3 inflammasome. Our results demonstrate the ability of Fc11a-2 to inhibit NLRP3 inflammasome activation and its potential use in the treatment of inflammatory bowel diseases.



3. LL Feng, XF Wu, HL Liu, WJ Guo, Q Luo, FF Tao, Y Shen, HM Ge, RX Tan, Q Xu*, Y Sun*. Vaticaffinol, a resveratrol tetramer, exerts more preferable immunosuppressive activity than its precursor in vitro and in vivo through multiple aspects against activated T lymphocytes. Toxicol Appl Pharma 2013; 267: 167-173.  (*correspondence-authorship) Download


Highlight: This study aimed to investigate the immunosuppressive activity of vaticaffinol, a resveratrol tetramer isolated from Vatica mangachapoi, on T lymphocytes both in vitro and in vivo, and further explored its potential molecular mechanism. Our findings suggest that vaticaffinol exerts more preferable immunosuppressive activity than its precursor resveratrol both in vitro and in vivo by affecting multiple targets against activated T cells.



4. F Tao, C Qian, W Guo, X Wu, Q Xu*, Y Sun*. Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin. Biochem Pharmacol 2013; 85: 798-807.  (*correspondence-authorship)   Download

Highlight: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestine which involves overproduction of pro-inflammatory cytokines and excessive functions of inflammatory cells. However, current treatments for IBD may have potential adverse effects including steroid dependence, infections and lymphoma. Therefore new therapies or drug candidates for the treatment of IBD are desperately needed. This paper reported that icariin, a major bioactive compound from plants in Epimedium family, exerted protective effect on intestinal inflammation in mice induced by dextran sulfate sodium through inhibiting the phosphorylations of STAT1 and STAT3 in CD4+ T cells, which were the crucial transcription factors for Th1 and Th17 respectively.




5. XY Fang, W Chen, JT Fan, R Song, L Wang, YH Gu, GZ Zeng, Y Shen, XF Wu, NH Tan, Q Xu*, Y Sun*. Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction. Toxicol Appl Pharma 2013; 267: 95-103. (*correspondence-authorship)  Download

Highlight: This study shows a natural cyclopeptide RA-V with strong anti-tumor activity against human breast cancer, which can induce mitochondria-mediated apoptosis. Its mechanism is related to the blockage of the interaction between PDK1 and AKT. Our data provide the molecular theoretical basis for clinical application of RA-V in patients with breast cancer.




6. Z Gao, W Chen, X Zhang, P Cai, X Fang, Q Xu*, Y Sun*, Y Gu*. Icotinib, a potent and specific EGFR tyrosine kinase inhibitor, inhibits growth of squamous cell carcinoma cell line A431 through negatively regulating AKT signaling. Biomedicine & Pharmacotherapy, 2013; 67: 351-356. (*correspondence-authorship)

7. W Li, Y Yang, Z Ouyang, Q Zhang, L Wang, F Tao, Y Su, Y Gu, Q Xu*, Y Sun*. Xiao-Ai-Ping, a TCM injection, enhances the antigrowth effects of cisplatin on Lewis lung cancer cells through promoting the infiltration and function of CD8+ T lymphocytes. Evidence-Based Complementary and Alternative Medicine, 2013, Article ID 879512, 9 pages.  Download






8. T Zhang, W Guo, Y Yang, W Liu, L Guo, Y Gu, Y Shu, L Wang, X Wu, Z Hua, Y Ke, Y Sun*, Y Shen*, Q Xu*. Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis. Sci Rep 2013; 3: 2845. Download




9. Q Luo, Y Sun*, W Liu, C Qian, B Jin, F Tao, Y Gu, X Wu, Y Shen, Y Shu, Q Xu*. Iguratimod, a novel disease modifying anti-rheumatic drug, attenuates collagen-induced arthritis in mice via blocking IL-17 signaling distinct from methotrexate and leflunomide. J Immunol, 2013; 191(10): 4969-4978. Download



 

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