1.  Wu LM, Wu XX, Sun Y, Kong XW, Zhang YH, Xu Q. A novel synthetic oleanolic acid derivative (CPU-II(2)) attenuates liver fibrosis in mice through regulating the function of hepatic stellate cells. J. Biomed. Sci. 2008; 15: 251-259. 

2. Wei Zhao, Yanhong Gu, Ran Song, Bingqian Qu and Qiang Xu. Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation. Leukemia 2008; 22(6): 1226-33.

Highlight: Sorafenib, a novel drug for metastatic renal cancer, has broad-spectrum activity against multiple tyrosine kinases, including Raf-1, vascular endothelial growth factor receptor and platelet-derived growth factor receptor. However, little is known about its effects on the immune system. In this report, we examine the effects of sorafenib on the proliferation and activation of human peripheral blood T cells, as well as its effects on T-cell-mediated immune response in mice. At concentrations similar to those used in patients, sorafenib inhibited the proliferation of primary human T cells in vitro. At more than 10 microM, sorafenib caused an irrecoverable inhibition of proliferation, even after drug withdrawal. In addition, sorafenib induced T-cell apoptosis at concentrations higher than 10 microM. sorafenib also caused G(0)/G(1) phase arrest, inhibition of CD25 and CD69 expression, interleukin-2 production and LCK phosphorylation in the T cells; all of these effects exhibited dose and time dependence. When tested against contact dermatitis in mice, sorafenib significantly reduced the ear swelling induced by picryl chloride. These findings suggest that sorafenib may cause the loss of T-cell immune response by inducing apoptosis and targeting LCK. This could potentially lead to immunosuppression in patients with cancer.

3. Liu K, Xu Q. Roxithromycin inhibits the effector phase of delayed-type hypersensitivity. Int Immunopharmacol. 2008; 8: 126-131.
4. Xin Sheng, Xun Guo, Xiao-Min Lu, Guo-Yuan Lu, Ying Shao, Fang Liu, Qiang Xu*.  DNA Binding, Cleavage, and Cytotoxic Activity of the Preorganized Dinuclear Zinc(II) Complex of Triazacyclononane Derivatives. Bioconjug Chem. 2008; 19: 490-498.
5. Ying Lao Zhang, Hui Ming Ge, Wei Zhao, Hao Dong, Qiang Xu, Shu Hua Li, Jing Li, Jie Zhang, Yong Chun Song, Ren Xiang Tan. Unprecedented Immunosuppressive Polyketides from Daldinia eschscholzii, a Mantis-associated Fungus. Angew. Chem. Int. Ed. 2008; 47: 5823-5826. 
6. Hong-wei Yi, Xiao-min Lu, Feng Fang, Jun Wang, Qiang Xu. Astilbin inhibits the adhesion of T lymphocytes via decreasing TNF-α and its associated MMP-9 activity and CD44 expression. Int. Immunopharmacol. 2008; 8: 1467-1474.
7. Ye Yin, Fang-yuan Gong, Xing-xin Wu, Yang Sun, Yi-hua Li, Ting Chen, Qiang Xu. Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. J. Ethnopharmacol. 2008; 120 (1): 1-6.
8. Fangyuan Gong, Yan Shen, Chaofeng Zhang, Jianliang Xu, Xuefeng Wu, Zichun Hua, Qiang Xu. Dregea volubilis ameliorates concanavalin A-induced liver injury by facilitating apoptosis of activated T cells. Exp. Biol. Med. 2008; 233(9):1124-32. 
9. Xia Sheng, Yang Sun, Ye Yin, Ting Chen, Qiang Xu. Cirsilineol inhibits proliferation of cancer cells by inducing apoptosis via mitochondrial pathway. J. Pharm. Pharmacol. 2008; 60(11): 1523-9.
10. Wen Lv, Xia Sheng, Ting Chen, Qiang Xu, and Xing Xie. Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway. J Biomed Biotechnol. 2008; 2008: 394802.   

 

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