1.Yang Sun, Yu Qin, Fang-Yuan Gong, Xue-Feng Wu, Zi-Chun Hua, Ting Chen and Qiang Xu. Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice. Biochem Pharmacol 2009; 77: 1717-1724.

2. Guo-Biao Liu, Jian-Liang Xu, Cui-Cui He, Gong Chen, Qiang Xu, Hong-Xi Xu, Jian-Xin Li. Synthesis and evaluation of a novel series of quinoline derivatives with immunosuppressive activity. Bioorganic & Medicinal Chemistry 2009; 17: 5433-5441.

3. Xiao-dan Wang, Min-xin Menga, Ling-bo Gaoa, Ting Liua, Qiang Xu, Su Zeng. Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp. International Journal of Pharmaceutics 2009; 378: 1-8. 

4. Yang Sun, Yi Dong, Huijuan Jiang, Tiantian Cai, Liang Chen, Xiang Zhou, Ting Chen, Qiang Xu. Dissection of the role of paeoniflorin in the traditional Chinese medicinal formula Si-Ni-San against contact dermatitis in mice. Life Sciences 2009; 84: 337-44.

Highlight: The roles of specific active ingredients in Chinese medicinal formulas have not been clearly elucidated. In this study, we selectively deleted and replenished paeoniflorin from Si-Ni-San, a traditional Chinese prescription, and aimed to identify the molecular basis of how paeoniflorin exerted its effect in Si-Ni-San. Our data indicate paeoniflorin is the principal component of Si-Ni-San, exerting negative regulation on the function of macrophages in contact dermatitis. The present study suggests that dissecting the role of specific constituents in medicinal formulas through selective deletion and replenishment may be a useful strategy in recognizing and validating an active ingredient in traditional Chinese medicine.

5. Xiang Zhou, Jianxin Li, Qiang Xu, Ting Chen. Structural Revision of Two Flavanonol Glycosides from Smilax glabra. Planta Med. 2009;75: 654-655.

6. Ran Song, Feng Qian, Yu-Pei Li, Xia Sheng, Shao-Xian Cao, Qiang Xu. Phosphatase of Regenerating Liver-3 Localizes to Cyto-membrane and Is Required for B16F1 Melanoma Cell Metastasis in vitro and in vivo. PLoS One 2009; 4(2): e4450.

7. Yan Liang, Qiang Xu, An Kang, Yuan Xie, Tong Xie, Li Liu, Haiping Hao, Lin Xie, Guang-ji Wang. Validation and application of an LC–ESI-MS method for simultaneous determination of astilbin and its major metabolite 3_-O-methylastilbin in rat plasma. Journal of Chromatography B 2009; 877: 1765-1770.

8. Yanhong Gu, Yongqian Shu and Qiang Xu. A study of weekly paclitaxel plus 5-fluorouracil and cisplatin for patients with advanced or recurrent inoperable gastric cancer. Biomedicine & Pharmacotherapy 2009; 63: 293-296.

9. Yang Sun, Tian-Tian Cai, Xiao-Bin Zhou, Qiang Xu. Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis. International Immunopharmacology 2009; 9: 978-983. 

10. Y Sun, TT Cai, Y Shen, XB Zhou, T Chen, Q Xu. Si-Ni-San, a traditional Chinese prescription, and its active ingredient glycyrrhizin ameliorate experimental colitis through regulating cytokine balance. Int Immunopharmacol, 2009; 9: 1437-1443.

11. L Wang, Y Shen, R Song, Y Sun, J Xu, Q Xu. An anticancer effect of curcumin mediated by down-regulating phosphatase of regenerating liver-3 expression on highly metastatic melanoma cells. Mol Pharmacol 2009; 76(6):1238-1245.

12. Q Xu, Y Sun. Novel immunosuppression stemming from the selective activity of Chinese herbal drugs. Prog Chem 2009; 21(1): 55-62.

Highlight: Despite the marked progress in immunology, the research and development of the remedies for immune diseases really dropped behind those for others. The broad-spectrum inhibition on various cells or tissues is the main problem existing in current immunosuppressive agents. Such low selectivity of the drug effect usually leads to the discontinuity of therapy for patients, who should receive long-term treatment. Thus, a new pathway is required for the discovery of remedies for immune diseases. This review summarizes some results on Chinese herbal drugs and their principles obtained in author's laboratory after an overview of the current immunosuppressants for comparison. A novel regulation on immune response, selective inhibition of activated T lymphocytes, and its possible application as a selective immunosuppressive therapy are suggested.

 

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