1. Y Sun, XX Wu, Y Yin, FY Gong, Y Shen, TT Cai, XB Zhou, XF Wu, Q Xu*. Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-γ signaling in a murine model of inflammatory bowel disease. Biochem Pharmacol 2010; 79: 229-238. 

Highlight: Regulation of signal transducer and activator of transcription (STAT) 1 signaling is being explored as a new approach to the treatment of inflammatory bowel diseases. However, few chemicals have been reported to inhibit IFN-gamma/STAT1 signaling for Crohn's disease therapy. This paper reported that cirsilineol, a small natural compound isolated from Artemisia vestita, significantly ameliorated trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice through inhibiting IFN-gamma-STAT1-T-bet signaling.



2. Y Gu, W Zhao, F Meng, B Qu, X Zhu, Y Sun, Y Shu, Q Xu. Sunitinib impairs the proliferation and function of human peripheral T cell and prevents T-cell-mediated immune response in mice. Clin Immunol 2010; 135(1): 55-62.

3. F Gong, Y Shen, Q Zhang, Y Sun, J Tang, F Tao, Q Xu. Obaculactone suppresses Th1 effector cell function through down-regulation of T-bet and prolongs skin graft survival in mice. Biochem Pharmacol 2010; 80: 218-225.


4. Feng Fang, Yijun Tang, Zhe Gao, Qiang Xu*. A novel regulatory mechanism of naringenin through inhibition of T lymphocyte function in contact hypersensitivity suppression. Biochemical and Biophysical Research Communications 2010; 397: 163-169.

5. Guo-Biao Liu, Jian-Liang Xu, Mei Geng, Rui Xu, Rong-Rong Hui, Jian-Wei Zhao, Qiang Xu, Hong-Xi Xu, Jian-Xin Li. Synthesis of a novel series of diphenolic chromone derivatives as inhibitors of NO production in LPS-activated RAW264.7 macrophages. Bioorganic & Medicinal Chemistry 2010; 18: 2864-2871.

6. Hui Ming Ge, Wen Hao Yang, Yan Shen, Nan Jiang, Zhi Kai Guo, Qiong Luo, Qiang Xu, Jing Ma, Ren Xiang Tan*. Immunosuppressive Resveratrol Aneuploids from Hopea chinensis. Chem. Eur. J. 2010, 16: 6338-6345.



 

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