1. L Wang, R Song, Y Shen, Y Sun, Y Gu, Y Shu, Q Xu. Targeting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma. Mol Cancer Ther 2011; 10: 461-471.

Highlight: Human liposarcoma is the most common soft tissue sarcoma. There is no effective therapy so far except for surgery. In this study, we report for the first time that curcumin induces endoplasmic reticulum (ER) stress in human liposarcoma cells via interacting with sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2). Curcumin dose-dependently inhibited the cell survival of human liposarcoma cell line SW872 cells, but did not affect that of human normal adipose-derived cells. Curcumin-mediated ER stress via inhibiting the activity of SERCA2 caused increasing expressions of CHOP and its transcription target death receptor 5 (TRAIL-R2), leading to a caspase-3 and caspase-8 cascade-dependent apoptosis in SW872 cells in vitro and in vivo. Moreover, 70% of human liposarcoma tissues showed an elevated SERCA2 expression compared with normal adipose tissues. Curcumin dose-dependently inhibited the activity of SERCA2, and the interaction of molecular docking and colocalization in ER of curcumin with SERCA2 were further observed. These findings suggest that curcumin may serve as a potent agent for curing human liposarcoma via targeting SERCA2.

2. Wang L, Wang LX, Gu Y, ShuY, Shen Y, Q Xu. Integrin a6high cell population functions as an initiator in tumorigenesis and relapse of human liposarcoma. Mol Cancer Ther 2011; 10: 2276-86.

Highlight: The relapse and resistance to chemo- and radiotherapy are main problems in the treatment of human liposarcoma. It is important to find a functional marker existing in the liposarcoma cells for targeting. This paper provide evidence, for the first time, to our knowledge, that integrin α6 and CD13 can serve as functional markers of the tumor-initiation subcell population in human liposarcoma as well as other cancers for therapeutic targeting.

3. Y Shen, Q Luo, H Xu, F Gong, X Zhou, Y Sun, X Wu, W Liu, G Zeng, N Tan, Q Xu. Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis. Biochem Pharmacol, 2011; 82(3): 260-268.

4. W Zhao, T Zhang, X Wu, B Qu, X Zhu, F Meng, Y Gu, Y Shu, Y Shen, Y Sun*, Q Xu*. Sorafenib induces apoptosis of human acute myeloid leukemia HL60 cells through Src-STAT3 signaling pathway. Anti-cancer drugs 2011; 22(1): 79-88. (*share correspondence-authorship)

5. Y Yin, Y Sun, L Gu, W Zheng, F Gong, X Wu, Q Xu*. Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. Eur J Pharmacol 2011; 651: 205-211.

6. Q Luo, Y Gu, W Zheng, X Wu, F Gong, L Gu, Y Sun*, Q Xu*. Erlotinib inhibits T-cell-mediated immune response via down-regulation of the c-Raf/ERK cascade and Akt signaling pathway. Toxicol Appl Pharma 2011; 251: 130-136. (*share correspondence-authorship)

7. XX Wu, LM Wu, JJ Fan, Y Qin, G Chen, Y Sun*, Q Xu*. Cortex Dictamni extract induces apoptosis of activated hepatic stellate cells via STAT1 and attenuates liver fibrosis in mice. J Ethnopharmacol 2011; 135(1): 173-178. (*share correspondence-authorship)

8. Xu J, Cao S, Wang L, Xu R, Chen G, et al. VEGF Promotes the Transcription of the Human PRL-3 Gene in HUVEC through Transcription Factor MEF2C. PLoS ONE 2011; 6(11): e27165.

9. Ge HM, Yan W, Guo ZK, Luo Q, Feng R, Zang le Y, Shen Y, Jiao RH, Xu Q, Tan RX. Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. Chem Commun (Camb). 2011; 47(8): 2321-3.


 

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